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The motivation to eat well follows from the physical improvement, rather than the peptide suppressing hunger signals directly

It is a selective agonist of the ghrelin receptor (GHS-R1a) and is characterized by high selectivity in receptor-signaling assays without significant effects on other pituitary hormones

Pituitary and hypothalamic signaling: Experiments evaluating downstream intracellular pathways in pituitary somatotrophs and hypothalamic circuits in response to combined ghrelin receptor and GHRH receptor stimulation